In Nebraska, 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) as well as acetolactate synthase (ALS)-inhibitor-resistant weeds occur in many soybean fields where herbicides from these modes-of-action have been frequently used in the past. Currently, the protoporphyrinogen oxidase (PPO)-inhibitors are the only effective herbicides for POST control of both glyphosate- and ALS-inhibitor-resistant weeds in soybean. Greenhouse experiments were conducted in 2014 to evaluate the efficacy of PPO-inhibitors applied POST for the control of three glyphosate-resistant (GR) weeds and potential for soybean injury, when applied at two growth stages. All herbicide treatments controlled 10- and 20-cm tall GR common waterhemp ≥ 95% at 21 DAT. GR giant ragweed and kochia were controlled 86 to 99% when treated at 10-cm height and 78 to 92% at 20-cm height by 21 DAT. Herbicide treatments reduced shoot biomass in the three GR weeds 88 to 100% when treated at 10-cm height and 73 to 100% when treated at 20-cm height, at 21 DAT. Soybean injury and shoot biomass data revealed that acifluorfen and lactofen were more injurious (≥ 17%), whereas fomesafen, and fomesafen plus glyphosate were relatively safer (\u3c 10% injury). Overall, fomesafen and fomesafen plus glyphosate caused least injury to soybean and were more effective in controlling GR common waterhemp, giant ragweed, and kochia compared with acifluorfen and lactofen.
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